Residential investment capital in the world is getting more liquid with the use of technology. The Middle East and North African (MENA) region has its allure in attracting upper-end residential investment from Casablanca to Dubai. Residential investment in Africa is also starting to pick up. This paper will use the Global Property Guide to examine different price and investment yield trends for the upper-end residential property in selected city across Africa and the Middle East. The data available is for the period between 2005 and 2010, although some countries only have data for 2009 and 2010. It is interesting to note the decline of the yield on investment compared over the past five years in most of the cities examined, although lower yields are not uniform. The MENA region and its sub-components, and African cities are compared to each other and to a baseline western market over place and time, holding productive type constant. Residential investment implications for the MENA region and Africa are set forth.